Applications of Murine Monoclonal Antibodies to the Salmonella Serogroup specific O and Vi antigens in the Clinical Microbiology Laboratory


Grant Data
Project Title
Applications of Murine Monoclonal Antibodies to the Salmonella Serogroup specific O and Vi antigens in the Clinical Microbiology Laboratory
Principal Investigator
Dr Tsang, Raymond Shiu Wah   (Principal investigator)
Start Date
1988-06-01
Amount
111960
Conference Title
Presentation Title
HKU Project Code
SRC
Grant Type
Strategic Research Fund (UPGC)
Funding Year
1987/1988
Status
Completed
Objectives
To raise murine monoclonal antibodies specific for the lipopolysaccharides of serogroups B, C1, and E Salmonella; together with the murine monoclonal antibodies already produced and characterized to be specific for the Vi and O antigens of serogroups A, C2, and D Salmonella, to investigate if the murine monoclonal antibodies to the Salmonella O factors and Vi antigen can be used to replace the conventional polyclonal O factor and Vi specific antisera for the seroplogical typing of Salmonella; to study the possibility of applying these murine monclonal antibodies to detect Salmonella in selective enrichment broth cultures; to study the feasibility of applying these murine monoclonal antibodies to detect Salmonella directly in clinical specimens or food products.