Significance of MAD2 expression to chromosomal instability in prostate cancer

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Grant Data
Project Title
Significance of MAD2 expression to chromosomal instability in prostate cancer
Principal Investigator
Dr Wang, Xianghong   (Principal Investigator (PI))
Co-Investigator(s)
NULL Wong Yong Chuan   (Co-Investigator)
Dr Jin Dong-Yan   (Co-Investigator)
Duration
36
Start Date
2004-04-01
Completion Date
2007-03-31
Amount
1746495
Conference Title
Significance of MAD2 expression to chromosomal instability in prostate cancer
Keywords
prostate cancer MAD2
Discipline
Cancer
HKU Project Code
N/A
Grant Type
Association for International Cancer Research - General Award
Funding Year
2004
Status
Completed
Objectives
To correlate MAD2 expression with genomic instability in prostate cancer specimens; to show that MAD2 expression is essential for a functional mitotic checkpoint in prostate cancer cells; to demonstrate that downregulation of MAD2 leads to mitotic checkpoint defect and increased CIN in prostate cancer cells. • To investigate if promoter hypermethylation contributes to decreased MAD2 expression in prostate cancer