Intracellular calcium signalling induced by ATP and histamine and the role of calcium in growth and differentiation in human leukemic HL-60 cells

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Grant Data
Project Title
Intracellular calcium signalling induced by ATP and histamine and the role of calcium in growth and differentiation in human leukemic HL-60 cells
Principal Investigator
Professor Loh, Tatt Tuck   (Principal Investigator (PI))
Co-Investigator(s)
Professor Kwan David Chiu Yin   (Co-Investigator)
Duration
48
Start Date
1994-07-01
Amount
1109000
Conference Title
Intracellular calcium signalling induced by ATP and histamine and the role of calcium in growth and differentiation in human leukemic HL-60 cells
Presentation Title
Keywords
null
Discipline
N/A
HKU Project Code
HKU 372/94M
Grant Type
General Research Fund (GRF)
Funding Year
1994
Status
Completed
Objectives
To delineate the transient nature of calcium influx induced by extracellular ATP and histamine; to study the relative dominance of the microsomal and plasmalemmal calcium pumps; to study the dynamics, functional size and refilling mechanisms of internal calcium pools in response to different agonists and pharmacological tools; to elucidate the cross-talk between the cAMP and Ca+2 signalling pathways; to define the role of Ca+2i in HL-60 cell growth and differentiation, and whether Ca+2i is related to the differentiation effect induced by retinoic acid, ATP and histamine.