Intracellular calcium signalling induced by ATP and histamine and the role of calcium in growth and differentiation in human leukemic HL-60 cells


Grant Data
Project Title
Intracellular calcium signalling induced by ATP and histamine and the role of calcium in growth and differentiation in human leukemic HL-60 cells
Principal Investigator
Professor Loh, Tatt Tuck   (Principal investigator)
Co-Investigator(s)
Professor Kwan David Chiu Yin   (Co-Investigator)
Duration
48
Start Date
1994-07-01
Completion Date
1998-06-30
Amount
1109000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 372/94M
Grant Type
General Research Fund (GRF)
Funding Year
1994/1995
Status
Completed
Objectives
To delineate the transient nature of calcium influx induced by extracellular ATP and histamine; to study the relative dominance of the microsomal and plasmalemmal calcium pumps; to study the dynamics, functional size and refilling mechanisms of internal calcium pools in response to different agonists and pharmacological tools; to elucidate the cross-talk between the cAMP and Ca+2 signalling pathways; to define the role of Ca+2i in HL-60 cell growth and differentiation, and whether Ca+2i is related to the differentiation effect induced by retinoic acid, ATP and histamine.