Intracellular calcium signalling induced by ATP and histamine and the role of calcium in growth and differentiation in human leukemic HL-60 cells
Professor Loh, Tatt Tuck (Principal investigator)
Professor Kwan David Chiu Yin (Co-Investigator)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
To delineate the transient nature of calcium influx induced by extracellular ATP and histamine; to study the relative dominance of the microsomal and plasmalemmal calcium pumps; to study the dynamics, functional size and refilling mechanisms of internal calcium pools in response to different agonists and pharmacological tools; to elucidate the cross-talk between the cAMP and Ca+2 signalling pathways; to define the role of Ca+2i in HL-60 cell growth and differentiation, and whether Ca+2i is related to the differentiation effect induced by retinoic acid, ATP and histamine.