To study the membrane signal transduction induced by transferrin binding to surface receptors and whether these activities are co-ordinated with the transmembrane redox system during cell activation and growth


Grant Data
Project Title
To study the membrane signal transduction induced by transferrin binding to surface receptors and whether these activities are co-ordinated with the transmembrane redox system during cell activation and growth
Principal Investigator
Professor Loh, Tatt Tuck   (Principal investigator)
Duration
48
Start Date
1990-07-01
Completion Date
1994-06-30
Amount
1109000
Conference Title
Presentation Title
HKU Project Code
HKU 20/90
Grant Type
University Grants Committee - General Award
Funding Year
1990/1991
Status
Completed
Objectives
To elucidate the identity of intracellular second messengers, the enzymatic mediator and their interacting framework that are responsible for linking the endocytotic and redox activity; prerequisite to this study is the establishment that transferrin binding will lead to the cascade reactions in membrane signal transduction; to characterize the subsequent initial cellular responses induced by controlled endocytotic and redox activity through the manipulation of intracellular and/or extracellular environments.