To study the membrane signal transduction induced by transferrin binding to surface receptors and whether these activities are co-ordinated with the transmembrane redox system during cell activation and growth
Professor Loh, Tatt Tuck (Principal investigator)
HKU Project Code
University Grants Committee - General Award
To elucidate the identity of intracellular second messengers, the enzymatic mediator and their interacting framework that are responsible for linking the endocytotic and redox activity; prerequisite to this study is the establishment that transferrin binding will lead to the cascade reactions in membrane signal transduction; to characterize the subsequent initial cellular responses induced by controlled endocytotic and redox activity through the manipulation of intracellular and/or extracellular environments.