Pharmacogenetics : variation in haloperidol reduction in man and animals


Grant Data
Project Title
Pharmacogenetics : variation in haloperidol reduction in man and animals
Principal Investigator
Dr Chan, Maureen Mo Yin   (Principal investigator)
Start Date
1991-06-24
Amount
310000
Conference Title
Presentation Title
HKU Project Code
HKU 41/91
Grant Type
General Research Fund (GRF)
Funding Year
1991/1992
Status
Completed
Objectives
To delineate the tissue and species variation in ketone (haloperidol) reductase activity and to screen the local Chinese population for genetic polymorphism in the metabolism of haloperidol. Anecdotal reports suggested that the Chinese patients required a much lower dose of haloperidol to attain the desired therapeutic effect. A knowledge of the metabolic pattern of haloperidol in the H.K. population will be of value in the effective clinical usage of haloperidol and related compounds.