Application of recombinant DNA technology in genetic diseases


Grant Data
Project Title
Application of recombinant DNA technology in genetic diseases
Principal Investigator
Ms. Todd, David   (Principal investigator)
Start Date
1986-02-05
Amount
1795000
Conference Title
Presentation Title
Grant Type
Croucher Foundation - Research Grants
Funding Year
1986/1987
Status
Completed
Objectives
To simplify the technique for quantitation of globin genes; to identify the specific a gene mutants responsible for [beta] thalassemia in Chinese by direct synthetic oligonucleotide probe analysis; to clone and sequence two abnormal [alpha] globin genes responsible for sever nondeleton [alpha] thalassemia and four new [beta] thalassemia mutants in the Chinese; to determine the restriction fragment length polymorphsim associated with haemophilia and Christmas Disease in Chinese.