Effect of prenatal exposure on urethane on the development expression of pulmonary and hepatic enzymes in the mouse


Grant Data
Project Title
Effect of prenatal exposure on urethane on the development expression of pulmonary and hepatic enzymes in the mouse
Principal Investigator
Professor Yeung, Desmond Chak Yew   (Principal investigator)
Co-Investigator(s)
Dr Ton Carl Chun Tsang   (Co-Investigator)
Dr Wong Susanna Siu Chun   (Co-Investigator)
Start Date
1984-06-01
Amount
10000
Conference Title
Presentation Title
Grant Type
Wing Lung Bank Medical Research Fund
Funding Year
1987/1988
Status
Completed
Objectives
To gain information on the sensitivity of embryonic tissues at different stages of organogenesis to carcinogenic effects of urethane; to apply the proposal of Snell for use of developmental enzyme anomalies as sensitive indicators of latent toxicological injury to the embryo or foetus; and to employ Weber's "molecular correlation" and "key enzyme" concepts of neoplasia to select appropriate enzyme markers for monitoring the developmental arrest or malignant transformation of foetal tissues.