Effect of prenatal exposure on urethane on the development expression of pulmonary and hepatic enzymes in the mouse
Professor Yeung, Desmond Chak Yew (Principal investigator)
Dr Ton Carl Chun Tsang (Co-Investigator)
Dr Wong Susanna Siu Chun (Co-Investigator)
Wing Lung Bank Medical Research Fund
To gain information on the sensitivity of embryonic tissues at different stages of organogenesis to carcinogenic effects of urethane; to apply the proposal of Snell for use of developmental enzyme anomalies as sensitive indicators of latent toxicological injury to the embryo or foetus; and to employ Weber's "molecular correlation" and "key enzyme" concepts of neoplasia to select appropriate enzyme markers for monitoring the developmental arrest or malignant transformation of foetal tissues.