The effect of ribonucleotide concentration on codon usage bias of mitochondrial and nuclear genomes of mammalian species
Dr Xia, Xuhua (Principal investigator)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
To evaluate the relative importance of three competing hypotheses: translation, mutation and transcription, proposed to explain the observed pattern of codon usage in various animal species, with particular emphasis on testing the validity of the transcription hypothesis of codon usage, THCU; to use DNA sequences from introns and orthologous protein genes to examine the generality of an optimality model of the RNA transcription process that has been used to predict the effect of maximizing transcription efficiency on codon usage; to develop methods and computer programs for codon analysis by automating analytical procedures such as data retrieval from GenBank, data manipulation, phylogenetic reconstruction, and phylogeny-based comparative analysis.