The anatomical basis of transformation invasion and metastasis in malignant melanoma in vivo: a combined immunohistochemical and morphometric investigation
Professor Weatherhead, Brian (Principal investigator)
Professor White Francis Harold (Co-Investigator)
Lee Wing Tat Fund
To characterise certain structural features of both melanocytes and melanoma cells, and of the extracellular matrix during malignant transition in an experimental carcinogenesis system in vivo. This will permit us to determine those structural features which may be involved in halting or promoting the transformation of normal melanocytes and the subsequent invasion and metastasis of malignant melanoma. These data will also be correlated with the criteria introduced by Breslow and by Clark with a view to extending and refining the current structural bases for diagnosis and prognosis.