The anatomical basis of transformation invasion and metastasis in malignant melanoma in vivo: a combined immunohistochemical and morphometric investigation


Grant Data
Project Title
The anatomical basis of transformation invasion and metastasis in malignant melanoma in vivo: a combined immunohistochemical and morphometric investigation
Principal Investigator
Professor Weatherhead, Brian   (Principal investigator)
Co-Investigator(s)
Professor White Francis Harold   (Co-Investigator)
Duration
36
Start Date
1990-07-01
Completion Date
1993-06-30
Amount
3600
Conference Title
Presentation Title
Grant Type
Lee Wing Tat Fund
Funding Year
1989/1990
Status
Completed
Objectives
To characterise certain structural features of both melanocytes and melanoma cells, and of the extracellular matrix during malignant transition in an experimental carcinogenesis system in vivo. This will permit us to determine those structural features which may be involved in halting or promoting the transformation of normal melanocytes and the subsequent invasion and metastasis of malignant melanoma. These data will also be correlated with the criteria introduced by Breslow and by Clark with a view to extending and refining the current structural bases for diagnosis and prognosis.