In vitro screening for anti-retroviral agents
Dr Chow, Samson A (Principal investigator)
Dr Brown Patrick O. (Co-Investigator)
Mr Bloch (Co-Investigator)
Mrs Yeung (Co-Investigator)
Wing Lung Bank Medical Research Fund
As an essential step in their life cycle, retroviruses must integrate the viral genome into the host cell chromosome. An in vitro assay has been developed to monitor the process of retroviral integration. In this study, we will use the in vitro assay to screen Chinese medicinal herbal compounds (pure or in crude extract form) that can inhibit retroviral integration. The proposed project may shed light on the mechanism of DNA transposition. More importantly, this approach may lead to discovery of substances that have therapeutic values in the treatment of retrovirus-induced diseases, such as AIDS and certain forms of cancer.