Topography of cells expressing membrane proteases that may modulate B lymphocyte development in bone marrow
Dr Opstelten, Davina (Principal investigator)
Lee Wing Tat Fund
Membrane proteases, expressed by various cell types including hemopoietic cells, modulate responses of these cells to peptide hormones. In vitro studies indicate that three of these proteases, CD10, CD13 and BP1/6C3, play a role in B lymphocyte development in the bone marrow. To judge their significance for normal, physiological B lymphocyte differentiation, we will study, in sections of femora of normal mice, the topographical distribution of cells expressing mRNA for each of the membrane proteases, and their spatial relationship to B lymphocyte progenitor cells.