Release of newly-formed B lymphocytes from the bone marrow: molecular interactions with the adluminal side of sinusoidal endothelium


Grant Data
Project Title
Release of newly-formed B lymphocytes from the bone marrow: molecular interactions with the adluminal side of sinusoidal endothelium
Principal Investigator
Dr Opstelten, Davina   (Principal investigator)
Duration
12
Start Date
1993-07-01
Completion Date
1994-06-30
Amount
12000
Conference Title
Presentation Title
Grant Type
Wing Lung Bank Medical Research Fund
Funding Year
1993/1994
Status
Completed
Objectives
B lymphocytes are continuously produced in the bone marrow parenchyma. They leave the marrow by transit through the sinusoidal wall. Sinusoidal lumina are often loaded with newly-formed B lymphocytes, and are hard to displace by perfusion, suggesting that they actually adhere to the adluminal side of endothelium. A stage of adherence might serve selective mechanisms such as tolerance induction. We propose to study molecular interactions involved.