Role of Chinese medicinal compounds in the regulation of stress-activated protein kinase in ischaemia/reperfusion


Grant Data
Project Title
Role of Chinese medicinal compounds in the regulation of stress-activated protein kinase in ischaemia/reperfusion
Principal Investigator
Dr Siow, Yaw Loong   (Principal investigator)
Duration
35
Start Date
1998-09-01
Completion Date
2001-07-31
Amount
735000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7297/98M
Grant Type
General Research Fund (GRF)
Funding Year
1998/1999
Status
Completed
Objectives
To investigate the biochemical and molecular mechanisms for the therapeutic use of tetramethylpyrazine (TMP), sodium tanshinone IIA sulphonate (STS) and ginkgo biloba in myocardial ischaemia/reperfusion. Specifically, I plan to determine whether these CChinese medicinal compounds have inhibitory effects against apoptosis mediated by the stress-activated protein (SAP) kinase pathway.