To examine the role of confined placental mosaicism in pregnancies complicated by fetal growth retardation and intrauterine fetal demise in Hong Kong


Grant Data
Project Title
To examine the role of confined placental mosaicism in pregnancies complicated by fetal growth retardation and intrauterine fetal demise in Hong Kong
Principal Investigator
Professor Lao, Terence Tzu Hsi   (Principal investigator)
Co-Investigator(s)
Dr Tang   (Co-Investigator)
Dr Lee   (Co-Investigator)
Dr Sin   (Co-Investigator)
Duration
48
Start Date
1996-09-01
Completion Date
2000-08-31
Amount
692000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 468/96M
Grant Type
General Research Fund (GRF)
Funding Year
1996/1997
Status
Completed
Objectives
To determine if the incidence of confined placental mosaicism in pregnancies complicated by fetal growth retardation and intrauterine death is significantly increased compared with incidence found in a control group of normal pregnancies delivering at term, and if so, whether placental tissue karyotpying should be part of the routine investigation in this cases; to examine the relationship between confined placental mosaicism and the obstetrical complications such as pre-eclampsia in pregnancies that resulted in a growth retarded or dead fetus; to determine if specific chromosomes are involved in the confined placental mosaicism that resulted in an adverse pregnancy outcome; to determine if the occurrence of confined placental mosaicism is related to certain epidemiological factors such as maternal age, socio-economic status, past obstetrical performance, and maternal nutritional status as reflected by the body mass index and haemoglobin at booking.