Protective effect of plant polyphenols on UV-induced skin photodamages
Grant Data
Project Title
Protective effect of plant polyphenols on UV-induced skin photodamages
Principal Investigator
Dr Wang, Mingfu
(Project Coordinator (PC))
Co-Investigator(s)
Dr Hu Shuting
(Co-Investigator)
Duration
17
Start Date
2017-09-01
Amount
282822
Conference Title
Protective effect of plant polyphenols on UV-induced skin photodamages
Presentation Title
Keywords
Plant Polyphenols, Protective Effect, Skin Photodamages, UV-induced
Discipline
Others - Biological Sciences
Panel
Physical Sciences (P)
HKU Project Code
InP/225/17
Grant Type
Innovation and Technology Fund Internship Programme
Funding Year
2016
Status
Completed
Objectives
Ultraviolet radiation in the sunlight is able to penetrate the atmosphere and lead cumulative injury to human skin. Clinically, photo damages include skin sunburn, inflammation, tanning and wrinkling. In addition, chronic exposure of the skin to UV radiation is a major etiologic risk factor for skin cancers. Currently, there is a world-wide trend to use natural products to protect the skin from harmful effects of UV irradiation. Topical application of some polyphenols such as green tea polyphenol, have great potential for the prevention or post-treatment of photoinduced damages such as UV-induced oxidation, DNA photoleisions, skin inflammation and sunburn. This study aims to find novel chemopreventive agents, particularly phytochemicals or plant extracts to protect human epidermal keratinocytes from UV irradiation induced damages. The targeted phytochemicals are stilbenes, flavonoids and stilbene-fused flavonoids. These discoveries in the future can be formulated into cosmetic or cosmeceutical product for the prevention or treatment of sunburn and photodamage.