A combined experimental and modeling investigation on the regulation of extracellular matrix viscosity on the adhesion and spreading of cells
Grant Data
Project Title
A combined experimental and modeling investigation on the regulation of extracellular matrix viscosity on the adhesion and spreading of cells
Principal Investigator
Professor Lin, Yuan
(Principal Investigator (PI))
Co-Investigator(s)
Professor Shenoy Vivek B
(Co-Investigator)
Dr Gu Zhizhan
(Co-Investigator)
Duration
36
Start Date
2019-01-01
Completion Date
2021-12-31
Amount
632421
Conference Title
A combined experimental and modeling investigation on the regulation of extracellular matrix viscosity on the adhesion and spreading of cells
Keywords
Biomechanics, Cell Adhesion, Cell Mechanics, Viscoelasticity
Discipline
Mechanics and Dynamics
Panel
Engineering (E)
HKU Project Code
17210618
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1) To establish protocols for fabricating substrates with distinct viscoelastic properties; 2) To systematically measure the adhesion and spreading response of cells cultured on different viscoelastic ECMs; 3) To model the growth of focal adhesions (FAs) regulated by substrate viscosity.