Nuclear p70 S6 kinase: a molecular determinant of early tumor metastasis?
Grant Data
Project Title
Nuclear p70 S6 kinase: a molecular determinant of early tumor metastasis?
Principal Investigator
Professor Wong, Alice Sze Tsai
(Principal Investigator (PI))
Co-Investigator(s)
Professor chan Ting Fung
(Co-Investigator)
Professor Cheung Annie Nga Yin
(Co-Investigator)
Professor Yam Judy Wai Ping
(Co-Investigator)
Duration
42
Start Date
2018-01-01
Completion Date
2021-06-30
Amount
905046
Conference Title
Nuclear p70 S6 kinase: a molecular determinant of early tumor metastasis?
Presentation Title
Keywords
adhesion, functional roles of genes, progression
Discipline
Molecular Biology
Panel
Biology and Medicine (M)
HKU Project Code
17103417
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To elucidate the functional roles of hnRNPA2/B1 and its specific pro-metastatic contribution in nuclear p70S6K-expressing cells 2 To decipher the molecular mechanism of nuclear translocalization of p70S6K 3 To unravel the underlying mechanisms of action of hnRNPA2/B1 in nuclear p70S6K-driven EMT, with particular reference to pre-mRNA splicing