Role of equilibrative nucleoside transporter-4 in the cardioprotection against ischemia-reperfusion injury in diabetes mellitus

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Grant Data
Project Title
Role of equilibrative nucleoside transporter-4 in the cardioprotection against ischemia-reperfusion injury in diabetes mellitus
Principal Investigator
Dr Leung, George Pak Heng   (Principal Investigator (PI))
Co-Investigator(s)
Professor Kwan Yiu Wa   (Co-Investigator)
Dr Tse Chung-Ming   (Co-Investigator)
Dr Xia Zhengyuan   (Co-Investigator)
Duration
36
Start Date
2018-01-01
Amount
745414
Conference Title
Role of equilibrative nucleoside transporter-4 in the cardioprotection against ischemia-reperfusion injury in diabetes mellitus
Presentation Title
Keywords
Adenosine, Cardioprotection, Ischemia, nucleoside transporters
Discipline
Pharmacology/Toxicology,Cardiovascular Research
Panel
Biology and Medicine (M)
HKU Project Code
17122417
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To confirm the contribution of ENT4 to adenosine transport in cardiomyocytes under ischemic condition 2 To compare the expressions and activities of ENT4 in cardiomyocytes under normal and diabetic conditions 3 To study the cardioprotective effect when ENT4 is pharmacologically inhibited or its expression is knocked out under normal and diabetic conditions