Repressor activator protein 1 increases the susceptibility to myocardial ischemia/reperfusion injury in type 2 diabetic mice

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Grant Data
Project Title
Repressor activator protein 1 increases the susceptibility to myocardial ischemia/reperfusion injury in type 2 diabetic mice
Principal Investigator
Professor Irwin, Michael Garnet   (Principal Investigator (PI))
Co-Investigator(s)
Dr Xia Zhengyuan   (Co-Investigator)
Dr Wong Gordon Tin Chun   (Co-Investigator)
Duration
36
Start Date
2018-01-01
Amount
1021360
Conference Title
Repressor activator protein 1 increases the susceptibility to myocardial ischemia/reperfusion injury in type 2 diabetic mice
Presentation Title
Keywords
CD36, ischemia/reperfusion injury, PPARĪ±, Rap1, type 2 diabetes
Discipline
Diabetes/Metabolism,Cardiovascular Research
Panel
Biology and Medicine (M)
HKU Project Code
17117217
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To investigate whether or not Rap1 increases the susceptibility to myocardial I/RI in type 2 diabetic rodents (in vitro, in vivo). 2 To observe whether or not Rap1 regulates cardiac energy metabolism during myocardial I/RI in type 2 diabetic rodents. 3 To assess whether or not Rap1 modulates cardiac metabolism in the context of myocardial I/RI through Rap1/ PPARĪ±/ CD36 signaling.