The roles of spermatozoa-oviductal epithelial cell interaction on the selection of fertilization-competent sperm and fertilization in humans

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Grant Data
Project Title
The roles of spermatozoa-oviductal epithelial cell interaction on the selection of fertilization-competent sperm and fertilization in humans
Principal Investigator
Dr Chiu, Chi Ngong   (Principal Investigator (PI))
Co-Investigator(s)
Professor Yeung William Shu Biu   (Co-Investigator)
Duration
42
Start Date
2018-01-01
Amount
1125910
Conference Title
The roles of spermatozoa-oviductal epithelial cell interaction on the selection of fertilization-competent sperm and fertilization in humans
Presentation Title
Keywords
Capacitation, Human spermatozoa, Oviduct, Sperm fucosyltransferase-5, Sperm selection
Discipline
Reproduction,Physiology
Panel
Biology and Medicine (M)
HKU Project Code
17116417
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To characterize the sFUT5-binding proteins on primary human OECs 2 To determine the role of sFUT5-binding proteins in spermatozoa-OEC interaction 3 To establish the relationship between capacitation and spermatozoa-OEC interaction 4 To study the role of sFUT5-mediated OEC adhesion in maintaining the quiescent state of human spermatozoa 5 To study the role of sFUT5-mediated OEC adhesion in selecting fertilization-competent sperm