Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response

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Grant Data
Project Title
Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response
Principal Investigator
Dr Cai, Yin   (Principal Investigator (PI))
Co-Investigator(s)
Professor Irwin Michael Garnet   (Co-Investigator)
Dr Xia Zhengyuan   (Co-Investigator)
Duration
27
Start Date
2017-08-01
Amount
1185856
Conference Title
Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response
Presentation Title
Keywords
apoptosis, inflammation, myocardial I/R injury, NLRP3, Rap1, Stat3
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
04151816
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2016
Status
Completed
Objectives
(1) To investigate whether or not Rap1 exacerbates myocardial ischemia/reperfusion (I/R) injury; (2) To evaluate the underlying molecular mechanisms whereby Rap1 impact on cardiac I/R injury.