Effects of microRNA-17-3p upregulation on vascular inflammation and endothelial dysfunction caused by the human immunodeficiency virus proteins
Grant Data
Project Title
Effects of microRNA-17-3p upregulation on vascular inflammation and endothelial dysfunction caused by the human immunodeficiency virus proteins
Principal Investigator
Dr Leung, Susan Wai Sum
(Principal Investigator (PI))
Co-Investigator(s)
Dr Lam Jenny Ka Wing
(Co-Investigator)
Duration
48
Start Date
2017-06-01
Completion Date
2022-11-24
Amount
1196800
Conference Title
Effects of microRNA-17-3p upregulation on vascular inflammation and endothelial dysfunction caused by the human immunodeficiency virus proteins
Keywords
endothelial dysfunction, HIV proteins, microRNA-17-3p, mouse aorta, nuclear factor-kappaB, vascular inflammation
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
16151212
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2016
Status
Completed
Objectives
Our preliminary experiments in human endothelial cells demonstrate that micro-ribonucleic acid (miRNA)-17-3p up-regulation reduces lipopolysaccharide-induced inflammation. Since miRNA-17 is down-regulated in HIV-infected patients by HIV protein Tat, we hypothesize that HIV proteins contribute to vascular inflammation and dysfunction partly by reducing miRNA-17-3p expression, and that these detrimental vascular effects can be reduced by increasing miRNA-17-3p expression.