Metadherin: a novel target for b-catenin and a critical mediator of the positive feedback loop between highly metastatic tumor cells and macrophages?
Grant Data
Project Title
Metadherin: a novel target for b-catenin and a critical mediator of the positive feedback loop between highly metastatic tumor cells and macrophages?
Principal Investigator
Professor Wong, Alice Sze Tsai
(Principal Investigator (PI))
Co-Investigator(s)
Dr Yuen Karen Wing Yee
(Co-Investigator)
Professor Lo Kwok Wai
(Co-Investigator)
Professor Cheung Annie Nga Yin
(Co-Investigator)
Duration
36
Start Date
2017-01-01
Amount
1092092
Conference Title
Metadherin: a novel target for b-catenin and a critical mediator of the positive feedback loop between highly metastatic tumor cells and macrophages?
Presentation Title
Keywords
adhesion, functional roles of genes, progression
Discipline
Molecular Biology
Panel
Biology and Medicine (M)
HKU Project Code
17141216
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To elucidate the specific contribution of Metadherin-driven HM on phenotypic and functional properties of macrophages and how the crosstalk may affect tumorigenic behavior 2 To decipher the molecular mechanism of b-catenin-Metadherin/CEACAM1-CCL3-driven polyploidy as a result of HM and macrophage interaction 3 To unravel the underlying mechanisms of the b-catenin-Metadherin/CEACAM1-CCL3 juxtacrine loop in regulating HM-macrophage interaction for rendering protumor phenotype