Defining the protective functional role of cyclooxygenase-1 in acute and chronic liver diseases
Grant Data
Project Title
Defining the protective functional role of cyclooxygenase-1 in acute and chronic liver diseases
Principal Investigator
Dr Tipoe, George Lim
(Principal Investigator (PI))
Co-Investigator(s)
Dr Ching Yick Pang
(Co-Investigator)
Dr Xiao Jia
(Co-Investigator)
Duration
42
Start Date
2016-07-01
Amount
1022514
Conference Title
Defining the protective functional role of cyclooxygenase-1 in acute and chronic liver diseases
Presentation Title
Keywords
animal model, cyclooxygenase, fattyy liver, inflammation, oxidative stress
Discipline
Pharmacology/Toxicology,Cell Biology
Panel
Biology and Medicine (M)
HKU Project Code
17156516
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To investigate the functional role and underlying molecular signaling pathways of COX-1 in the pathogenesis of liver injury in both acute and chronic liver injury animal models. 2 To evaluate the source of functional COX-1, whether it is produced in situ in the liver or induced by systemic inflammation processes. 3 To investigate whether there is a compensatory functional mechanism between COX-1 and COX-2 and the possible clinical application of COX inhibitors in treating both acute and chronic liver injury.