The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer

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Grant Data
Project Title
The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer
Principal Investigator
Dr Wong, Maria Pik   (Principal Investigator (PI))
Co-Investigator(s)
Dr Yam Judy Wai Ping   (Co-Investigator)
Duration
36
Start Date
2016-07-01
Amount
1245532
Conference Title
The role and mechanisms of CaMK2A/SOX2 coupling in tumor initiating cells regulation and drug resistance in non-small cell lung cancer
Presentation Title
Keywords
CaMK2A, drug resistance, Lung cancer, SOX2, Tumour initiating cells
Discipline
Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17150916
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To study the role of CaMK2A and CaMK2A/SOX2 coupling in TIC regulation of non-small cell lung cancer 2 To study the mechanism of SOX2 regulation by CaMK2A through EZH2 and H3K27me3 modification 3 To study the expression patterns of CaMK2A and its clinicopathological significance in human non-small cell lung cancer