The interactions of P. gingivalis persisters with human oral epithelial cells and monocytes: Molecular profiling and regulating mechanisms
Grant Data
Project Title
The interactions of P. gingivalis persisters with human oral epithelial cells and monocytes: Molecular profiling and regulating mechanisms
Principal Investigator
Professor Jin, Lijian
(Principal Investigator (PI))
Co-Investigator(s)
Dr Seneviratne Chaminda Jayampath
(Co-Investigator)
Dr Li Peng
(Co-Investigator)
Ms Li Xuan
(Co-Investigator)
Duration
36
Start Date
2016-12-01
Amount
1161120
Conference Title
The interactions of P. gingivalis persisters with human oral epithelial cells and monocytes: Molecular profiling and regulating mechanisms
Presentation Title
Keywords
Microbe-host interaction, Monocytes, Oral epithelial cells, P. gingivalis, Persisters
Discipline
Allergy/Immunology,Infection/Parasitology
Panel
Biology and Medicine (M)
HKU Project Code
17155216
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To examine the molecular profiles and antibiotic tolerance mechanisms of P. gingivalis persisters. 2 To explore the effect of our newly developed nano-encapsulated chlorhexidine on P. gingivalis persisters. 3 To investigate the host response of HOKs and THP-1 and the underlying regulatory mechanisms in their crosstalk with P. gingivalis persisters.