Study on regulation of expression of EBV BARTs and function of BART LncRNAs in nasopharyngeal carcinoma cells
Grant Data
Project Title
Study on regulation of expression of EBV BARTs and function of BART LncRNAs in nasopharyngeal carcinoma cells
Principal Investigator
Professor Chen, Honglin
(Principal Investigator (PI))
Duration
36
Start Date
2017-01-01
Amount
1029084
Conference Title
Study on regulation of expression of EBV BARTs and function of BART LncRNAs in nasopharyngeal carcinoma cells
Presentation Title
Keywords
Epstein-Barr virus, LncRNA, microRNA, Nasopharyngeal carcinoma, NFkapaB
Discipline
Microbiology,Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17154516
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To delineate the molecular details of how, and to what extent, the BART promoter is activated by NF-κB signalling in EBV infected NPC cells; 2 To characterize the role of LMP1 in regulation of miR-BARTs and Lnc-BARTs expression in EBV associated tumors through NF-κB signaling; 3 To define the spectrum and specificity of miR-BARTs and Lnc-BARTs involved in regulation of LMP1 expression and EBV latency in NPC cells; 4 To study the effect of downregulation of expression of EBV BARTs on EBV latency in NPC cells through intervention of NF-κB signaling with inhibitors and use of GapmeR to knockdown BART LncRNA in NPC cells.