Study on regulation of expression of EBV BARTs and function of BART LncRNAs in nasopharyngeal carcinoma cells
Professor Chen, Honglin (Principal investigator)
Epstein-Barr virus, Nasopharyngeal carcinoma, LncRNA, microRNA, NFkapaB
Biology and Medicine (M)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
2 To characterize the role of LMP1 in regulation of miR-BARTs and Lnc-BARTs expression in EBV associated tumors through NF-κB signaling; 3 To define the spectrum and specificity of miR-BARTs and Lnc-BARTs involved in regulation of LMP1 expression and EBV latency in NPC cells; 4 To study the effect of downregulation of expression of EBV BARTs on EBV latency in NPC cells through intervention of NF-κB signaling with inhibitors and use of GapmeR to knockdown BART LncRNA in NPC cells.