Generation and Synthetic Applications of C-Boron Enolates
Grant Data
Project Title
Generation and Synthetic Applications of C-Boron Enolates
Principal Investigator
Professor Chiu, Pauline
(Principal Investigator (PI))
Duration
36
Start Date
2015-09-01
Amount
706972
Conference Title
Generation and Synthetic Applications of C-Boron Enolates
Presentation Title
Keywords
Boron enolates, Boronic esters, Enol borates
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
17302415
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To study and elucidate the mechanism of this O- to C-boron rearrangement and characterize the species involved. 2 To study the addition of B2pin2 and other bisboron species 3 To study the scope of unsaturated esters and amide substrates for synthesizing the O-boron enolate, and rearranging to the C-boron enolate. 4 To examine the scope of the phosphines or other additives to promote the O- to C-boron enolate rearrangement. 5 To study the asymmetric rearrangement of O- to C-boron enolates 6 To study the functionalizations of the C-B bonds of C-boron enolates to C-O, C-N and C-C bonds.