Polyamine/Let-7 signaling in embryo implantation and diapause


Grant Data
Project Title
Polyamine/Let-7 signaling in embryo implantation and diapause
Principal Investigator
Professor Yeung, William Shu Biu   (Principal investigator)
Co-Investigator(s)
Professor Murphy Bruce Daniel   (Co-Investigator)
Dr Liu Weimin   (Co-Investigator)
Dr Lee Calvin Kai Fai   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
1012304
Conference Title
Presentation Title
Keywords
blastocyst, diapause, implantation, let-7, polyamines
Discipline
Reproduction
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17107915
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To determine the roles of steroids in the production of polyamines and let-7/let-7 containing exosomes in mouse endometrial cells. 3 To study the roles of uterine polyamines and let-7 in implantation/diapause in vivo. 4 To study the roles of hCG on polyamines and let-7 expression and function in human endometrial cells in vitro.