Optogenetic Functional MRI Investigation of Cortical Descending Modulation of Auditory Midbrain Processing
Grant Data
Project Title
Optogenetic Functional MRI Investigation of Cortical Descending Modulation of Auditory Midbrain Processing
Principal Investigator
Professor Wu, Ed Xuekui
(Principal Investigator (PI))
Co-Investigator(s)
Professor Sanes Dan H
(Co-Investigator)
Professor Tsia Kevin Kin Man
(Co-Investigator)
Duration
42
Start Date
2015-09-01
Amount
1077509
Conference Title
Optogenetic Functional MRI Investigation of Cortical Descending Modulation of Auditory Midbrain Processing
Presentation Title
Keywords
auditory, fMRI, midbrain, MRI, neuroimaging
Discipline
Imaging
Panel
Biology and Medicine (M)
HKU Project Code
17103015
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 Develop an o-afMRI protocol that integrates (i) optogenetic inhibition or excitation of pyramidal neurons in the AC and VC regions; and (ii) fMRI characterization of basic auditory processing functions in the IC, including gain of response and response selectivity to species-specific vocalizations. 2 Employ fMRI to characterize the functional influences of AC descending projections on IC auditory processing: Determine how auditory processing functions in all bilateral IC subdivisions are modulated by optogenetically manipulating the pyramidal neurons in three AC regions (Au1, AuD and Auv). 3 Employ fMRI to characterize the functional influences of VC cross-modal descending projections on IC auditory processing: Determine how auditory processing functions in IC subdivisions are modulated by optogenetically manipulating the pyramidal neurons in one secondary VC region (V2L).