Role of Brg1 in Sevoflurane Postconditioning Cardioprotection in Diabetes and Its Interplay with STAT3

View Statistics Email Alert RSS Feed

Grant Data
Project Title
Role of Brg1 in Sevoflurane Postconditioning Cardioprotection in Diabetes and Its Interplay with STAT3
Principal Investigator
Professor Irwin, Michael Garnet   (Principal Investigator (PI))
Co-Investigator(s)
Dr Yue Jianbo   (Co-Investigator)
Dr Xia Zhengyuan   (Co-Investigator)
Dr Wong Gordon Tin Chun   (Co-Investigator)
Duration
30
Start Date
2015-10-01
Amount
836372
Conference Title
Role of Brg1 in Sevoflurane Postconditioning Cardioprotection in Diabetes and Its Interplay with STAT3
Presentation Title
Keywords
Diabetes, Ischemia Reperfusion, Postconditioning, Sevoflurane
Discipline
Anaesthesia
Panel
Biology and Medicine (M)
HKU Project Code
17121315
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To determine the role of cardiac Brg1 in SevoPC and its impact on cardiac STAT3 and autophagy 2 To examine the effectiveness of Brg1 enhancement in attenuating myocardial IRI and restoring myocardial sensitivity to SevoPC in diabetes 3 To determine the role of STAT3 activation in Brg1-mediated restoration of the sensitivity of the diabetic heart to SevoPC