Role of Brg1 in Sevoflurane Postconditioning Cardioprotection in Diabetes and Its Interplay with STAT3


Grant Data
Project Title
Role of Brg1 in Sevoflurane Postconditioning Cardioprotection in Diabetes and Its Interplay with STAT3
Principal Investigator
Professor Irwin, Michael Garnet   (Principal investigator)
Co-Investigator(s)
Dr Yue Jianbo   (Co-Investigator)
Dr Xia Zhengyuan   (Co-Investigator)
Dr Wong Gordon Tin Chun   (Co-Investigator)
Duration
30
Start Date
2015-10-01
Completion Date
2018-03-31
Amount
836372
Conference Title
Presentation Title
Keywords
Postconditioning, Diabetes, Sevoflurane, Ischemia Reperfusion
Discipline
Anaesthesia
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17121315
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To examine the effectiveness of Brg1 enhancement in attenuating myocardial IRI and restoring myocardial sensitivity to SevoPC in diabetes 3 To determine the role of STAT3 activation in Brg1-mediated restoration of the sensitivity of the diabetic heart to SevoPC