Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes


Grant Data
Project Title
Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes
Principal Investigator
Professor Xu, Aimin   (Principal investigator)
Co-Investigator(s)
Professor Zhou Zhi Guang   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
1092383
Conference Title
Presentation Title
Keywords
islet beta-cells, autoimmune diabetes, inflammation, insulin, hyperglycemia
Discipline
Diabetes/Metabolism
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17128115
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To evaluate the contribution of NE and PR3 to dynamic changes on infiltration and composition of various immune cells and production of proinflammatory cytokines in NOD mice 3 To elucidate the molecular mechanisms by which NE and PR3 triggers insulitis and pancreatic β cell destruction by mediating immune cell crosstalk