Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes
Grant Data
Project Title
Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes
Principal Investigator
Professor Xu, Aimin
(Principal Investigator (PI))
Co-Investigator(s)
Professor Zhou Zhi Guang
(Co-Investigator)
Duration
36
Start Date
2016-01-01
Amount
1092383
Conference Title
Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes
Presentation Title
Keywords
autoimmune diabetes, hyperglycemia, inflammation, insulin, islet beta-cells
Discipline
Diabetes/Metabolism
Panel
Biology and Medicine (M)
HKU Project Code
17128115
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To determine whether NE and PR3 are the early mediators of insulitis and autoimmune diabetes in NOD mice, and to explore the therapeutic potential of islet-specific delivery of elafin for treating this disease 2 To evaluate the contribution of NE and PR3 to dynamic changes on infiltration and composition of various immune cells and production of proinflammatory cytokines in NOD mice 3 To elucidate the molecular mechanisms by which NE and PR3 triggers insulitis and pancreatic β cell destruction by mediating immune cell crosstalk