Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase


Grant Data
Project Title
Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Principal Investigator
Professor Zheng, Bojian   (Project coordinator)
Co-Investigator(s)
Dr Kao Richard Yi Tsun   (Co-Investigator)
Dr Zhou Jie   (Co-Investigator)
Duration
22
Start Date
2015-09-01
Completion Date
2017-06-30
Amount
323400
Conference Title
Presentation Title
Keywords
Anti-influenza Agents, Influenza Virus RNA Polymerase
Discipline
Others - Medicine, Dentistry and Health
Panel
Medicine
HKU Project Code
InP/218/15
Grant Type
Innovation and Technology Fund Internship Programme
Funding Year
2015/2016
Status
On-going
Objectives
3.1 To screen small molecular compounds that can inhibit enzyme activities or bindings between PA, PB1 and PB2; 3.2 To evaluate in vitro anti-H1N1 effects of the selected compounds; 3.3 To detect in vitro cross antiviral effects of the selected compounds and the peptides against different subtypes of influenza virus; 3.4 To test potential toxicity of the selected compounds and the peptides in cell cultures; 3.5 To optimize the compounds by further screening analogues of the effective compounds; 3.6 To assess potential synergistic antiviral effects between effective compounds targeting different subunits of viral polymerase and the peptides; 3.7 To evaluate prophylactic and therapeutic anti-influenza effects of the selected compounds in established animal models and the peptides; 3.8 To study antiviral mechanism of the selected compounds and the peptides.