Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Grant Data
Project Title
Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Principal Investigator
Professor Zheng, Bojian
(Project Coordinator (PC))
Co-Investigator(s)
Professor Zhou Jie
(Co-Investigator)
Professor Kao Richard Yi Tsun
(Co-Investigator)
Duration
22
Start Date
2015-09-01
Completion Date
2017-06-30
Amount
323400
Conference Title
Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Keywords
Anti-influenza Agents, Influenza Virus RNA Polymerase
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
InP/218/15
Grant Type
Innovation and Technology Fund Internship Programme
Funding Year
2015
Status
Completed
Objectives
3.1 To screen small molecular compounds that can inhibit enzyme activities or bindings between PA, PB1 and PB2; 3.2 To evaluate in vitro anti-H1N1 effects of the selected compounds; 3.3 To detect in vitro cross antiviral effects of the selected compounds and the peptides against different subtypes of influenza virus; 3.4 To test potential toxicity of the selected compounds and the peptides in cell cultures; 3.5 To optimize the compounds by further screening analogues of the effective compounds; 3.6 To assess potential synergistic antiviral effects between effective compounds targeting different subunits of viral polymerase and the peptides; 3.7 To evaluate prophylactic and therapeutic anti-influenza effects of the selected compounds in established animal models and the peptides; 3.8 To study antiviral mechanism of the selected compounds and the peptides.