Method and software tool for estimating and dissecting the heritability of complex diseases

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Grant Data
Project Title
Method and software tool for estimating and dissecting the heritability of complex diseases
Principal Investigator
Professor Sham, Pak Chung   (Principal Investigator (PI))
Co-Investigator(s)
Professor Li Miaoxin   (Co-Investigator)
Dr Cherny Stacey Shawn   (Co-Investigator)
Duration
36
Start Date
2015-11-01
Amount
1167288
Conference Title
Method and software tool for estimating and dissecting the heritability of complex diseases
Presentation Title
Keywords
Diseases, Genome, Heritability, Method, SNP
Discipline
Genomic Medicine
Panel
Biology and Medicine (M)
HKU Project Code
17128515
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To develop a novel method for estimating the variance (of a quantitative phenotype or of the liability to a binary disease phenotype) explained by a set of correlated genetic variants, using GWAS summary statistics (p-values) only 2 To extend this method for bivariate analysis of two phenotypes, to quantify the total shared variance explained by a set of correlated genetic variants. 3 To implement this methodology into a convenient web-based software.