Likelihood methods for assessing association and parent-of-origin effects using case-control pedigrees
Grant Data
Project Title
Likelihood methods for assessing association and parent-of-origin effects using case-control pedigrees
Principal Investigator
Professor Fung, Tony Wing Kam
(Principal Investigator (PI))
Duration
30
Start Date
2015-09-01
Amount
600000
Conference Title
Likelihood methods for assessing association and parent-of-origin effects using case-control pedigrees
Presentation Title
Keywords
association studies, genetic epidemiology, genomic imprinting, statistical genetics
Discipline
Genetic Disease
Panel
Biology and Medicine (M)
HKU Project Code
17301715
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To construct powerful statistical tests for association and parent-of-origin effects for qualitative traits. 2 To derive powerful statistical tests for association and parent-of-origin effects for quantitative traits and in the X-chromosome. 3 To apply the proposed methods to analyze real data such as for rheumatoid arthritis in which significant imprinting effects have been observed.