Novel Pituitary Actions of Neurokinin B (NKB) and NKB-Related Peptide in Fish Model: TAC3/NK3R System and its Interaction with Insulin-like Growth Factor in Somatolactin α Regulation in Carp Pituitary Cells


Grant Data
Project Title
Novel Pituitary Actions of Neurokinin B (NKB) and NKB-Related Peptide in Fish Model: TAC3/NK3R System and its Interaction with Insulin-like Growth Factor in Somatolactin α Regulation in Carp Pituitary Cells
Principal Investigator
Professor Wong, Anderson On Lam   (Principal investigator)
Duration
36
Start Date
2015-09-01
Completion Date
2018-08-31
Amount
1202424
Conference Title
Presentation Title
Keywords
Neurokinin B, Somatolactin, Insulin-like Growth Factor, Pituitary, Fish
Discipline
Comparative Endocrinology
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17128215
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To establish the role of carp NKBb as a novel antagonist for NK3R expressed in the carp pituitary and unveil the structural determinant in its C-terminal signature motif responsible for this antagonistic effect 3 To examine the role of NK3R expression and functional crosstalk in signal transduction for NK3R and IGF-I receptor in IGF potentiation of SLα expression in carp pituitary cells induced by TAC3 gene products.