Novel Pituitary Actions of Neurokinin B (NKB) and NKB-Related Peptide in Fish Model: TAC3/NK3R System and its Interaction with Insulin-like Growth Factor in Somatolactin α Regulation in Carp Pituitary Cells

Professor Wong, Anderson On Lam   (Principal Investigator (PI))

42

2015-09-01

1202424

Novel Pituitary Actions of Neurokinin B (NKB) and NKB-Related Peptide in Fish Model: TAC3/NK3R System and its Interaction with Insulin-like Growth Factor in Somatolactin α Regulation in Carp Pituitary Cells

Fish, Insulin-like Growth Factor, Neurokinin B, Pituitary, Somatolactin

Comparative Endocrinology

Biology and Medicine (M)

17128215

General Research Fund (GRF)

2015

Completed

1 To elucidate the functional role of NK3R and its associated post-receptor signaling for NKB- and NKBRP-induced SLα secretion, protein production and gene expression in primary culture of grass carp pituitary cells. 2 To establish the role of carp NKBb as a novel antagonist for NK3R expressed in the carp pituitary and unveil the structural determinant in its C-terminal signature motif responsible for this antagonistic effect 3 To examine the role of NK3R expression and functional crosstalk in signal transduction for NK3R and IGF-I receptor in IGF potentiation of SLα expression in carp pituitary cells induced by TAC3 gene products.