Role of Matrix Metalloproteinase 12 (MMP12) in Intervertebral Disc Fibrosis


Grant Data
Project Title
Role of Matrix Metalloproteinase 12 (MMP12) in Intervertebral Disc Fibrosis
Principal Investigator
Professor Cheung, Kenneth Man Chee   (Principal investigator)
Co-Investigator(s)
Dr Lv Fengjuan   (Co-Investigator)
Dr Leung Victor Yu Leong   (Co-Investigator)
Duration
36
Start Date
2015-11-01
Completion Date
2018-10-31
Amount
838941
Conference Title
Presentation Title
Keywords
intervertebral disc, degeneration, fibrosis, MMP12, low back pain
Discipline
Connective Tissues
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17104815
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To validate the contribution of MMP12 to disc homeostasis through MMP12 depletion in vitro and in vivo; 3 To investigate if and how MMP12 regulates the inflammatory signaling in IVD fibrosis.