Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming


Grant Data
Project Title
Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming
Principal Investigator
Dr Wong, Chun Ming   (Principal investigator)
Duration
36
Start Date
2015-11-01
Completion Date
2018-10-31
Amount
918205
Conference Title
Presentation Title
Keywords
Hepatocellular Carcinoma, Epigenetics, HELLS, Chromatin remodeling, Cancer metabolism
Discipline
Cancer
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17115815
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To investigate the mechanisms contributed to HELLS up-regulation in human HCC 3 To characterize the functions of HELLS in HCC growth and metastasis with in-vitro and in vivo models 4 To elucidate the roles of HELLS in HCC metabolic reprogramming and liver carcinogenesis