Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming
Grant Data
Project Title
Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming
Principal Investigator
Dr Wong, Chun Ming
(Principal Investigator (PI))
Duration
42
Start Date
2015-11-01
Amount
918205
Conference Title
Pathological roles of chromatin remodeling protein, HELLS, in liver carcinogenesis and its implications in cancer metabolic reprogramming
Presentation Title
Keywords
Cancer metabolism, Chromatin remodeling, Epigenetics, HELLS, Hepatocellular Carcinoma
Discipline
Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17115815
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To determine the expression changes of HELLS and its clinicopathological significance in human HCC 2 To investigate the mechanisms contributed to HELLS up-regulation in human HCC 3 To characterize the functions of HELLS in HCC growth and metastasis with in-vitro and in vivo models 4 To elucidate the roles of HELLS in HCC metabolic reprogramming and liver carcinogenesis