Functional role of PACT in limiting replication of influenza A virus


Grant Data
Project Title
Functional role of PACT in limiting replication of influenza A virus
Principal Investigator
Dr Kok, Kin Hang   (Principal investigator)
Duration
24
Start Date
2016-01-01
Completion Date
2017-12-31
Amount
697905
Conference Title
Presentation Title
Keywords
PACT, RIG-I, innate immunity, influenza A virus, PAR-CLIP
Discipline
Allergy/Immunology
Panel
Biology and Medicine (M)
Sponsor
RGC Early Career Scheme (ECS)
HKU Project Code
27121515
Grant Type
Early Career Scheme (ECS)
Funding Year
2015/2016
Status
On-going
Objectives
2 To identify and characterize PACT-associated RNP complexes i) PACT-associated viral RNAs ii) PACT-associated ribonucleoprotein complex . 3 To elucidate the molecular mechanism of PACT in the restriction of viral replication i) Characterization of dsRNA-binding domain of PACT for viral RNA binding ii) Analysis of the binding kinetics of PACT with viral RNAs