Functional role of PACT in limiting replication of influenza A virus
Grant Data
Project Title
Functional role of PACT in limiting replication of influenza A virus
Principal Investigator
Dr Kok, Kin Hang
(Principal Investigator (PI))
Duration
24
Start Date
2016-01-01
Amount
697905
Conference Title
Functional role of PACT in limiting replication of influenza A virus
Presentation Title
Keywords
influenza A virus, innate immunity, PACT, PAR-CLIP, RIG-I
Discipline
Allergy/Immunology
Panel
Biology and Medicine (M)
HKU Project Code
27121515
Grant Type
Early Career Scheme (ECS)
Funding Year
2015
Status
Completed
Objectives
1 To investigate the functional role of PACT in viral replication i) An inhibitory role of PACT in viral replication ii) Interferon-independent inhibition of viral replication . 2 To identify and characterize PACT-associated RNP complexes i) PACT-associated viral RNAs ii) PACT-associated ribonucleoprotein complex . 3 To elucidate the molecular mechanism of PACT in the restriction of viral replication i) Characterization of dsRNA-binding domain of PACT for viral RNA binding ii) Analysis of the binding kinetics of PACT with viral RNAs