Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions
Grant Data
Project Title
Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions
Principal Investigator
Professor Chan, Ying Shing
(Principal Investigator (PI))
Co-Investigator(s)
Dr Li Bin
(Co-Investigator)
Professor Wang Jian-Jun
(Co-principal investigator)
Dr Zhuang Qian-Xing
(Co-Investigator)
Dr Lai Chun Hong
(Co-Investigator)
Professor Shum Daisy Kwok Yan
(Co-Investigator)
Professor Yung Wing Ho
(Co-Investigator)
Duration
48
Start Date
2015-01-01
Amount
1098872
Conference Title
Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions
Presentation Title
Keywords
Development, Orexin, Spatial recognition, Synaptic plasticity, Vestibular system
Discipline
Neurobiology and Neuromedicine,Physiology
HKU Project Code
N_HKU735/14
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2014
Status
Completed
Objectives
1) To determine the regulatory role of orexin on long-term synaptic plasticity in the VN and cerebellum. 2) To investigate if neonatal perturbation of orexin neurons in the hypothalamus or orexin synapses in the VN has any effect on (a) the tuning of synaptic efficacy in the VN and cerebellum, (b) developmental formation of spatial map, and (c) maturation of vestibular-related behaviors. 3) To examine if perturbation of orexin neurons in the hypothalamus or orexin synapses in the VN applied towards the end of the postnatal period has any effect on the mature animal.