Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions


Grant Data
Project Title
Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions
Principal Investigator
Professor Chan, Ying Shing   (Principal investigator)
Co-Investigator(s)
Dr Lai Chun Hong   (Co-Investigator)
Professor Shum Daisy Kwok Yan   (Co-Investigator)
Dr Li Bin   (Co-Investigator)
Professor Yung Wing Ho   (Co-Investigator)
Dr Zhuang Qian-Xing   (Co-Investigator)
Professor Wang Jian-Jun   (Co-principal investigator)
Duration
48
Start Date
2015-01-01
Completion Date
2018-12-31
Amount
1098872
Conference Title
Presentation Title
Keywords
Orexin, Vestibular system, Development, Synaptic plasticity, Spatial recognition
Discipline
Neurobiology and Neuromedicine,Physiology
Panel
Medicine
Sponsor
NSFC/RGC Joint Research Scheme
HKU Project Code
N_HKU735/14
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2014/2015
Status
On-going
Objectives
1) To determine the regulatory role of orexin on long-term synaptic plasticity in the VN and cerebellum. 2) To investigate if neonatal perturbation of orexin neurons in the hypothalamus or orexin synapses in the VN has any effect on (a) the tuning of synaptic efficacy in the VN and cerebellum, (b) developmental formation of spatial map, and (c) maturation of vestibular-related behaviors. 3) To examine if perturbation of orexin neurons in the hypothalamus or orexin synapses in the VN applied towards the end of the postnatal period has any effect on the mature animal.