Nur77: new insights in signaling and mechanism of activation of epithelial-mesenchymal transition and tumor metastasis
Grant Data
Project Title
Nur77: new insights in signaling and mechanism of activation of epithelial-mesenchymal transition and tumor metastasis
Principal Investigator
Professor Wong, Alice Sze Tsai
(Principal Investigator (PI))
Co-Investigator(s)
Dr Zeng Jin-Zhang
(Co-principal investigator)
Duration
48
Start Date
2015-01-01
Amount
1097512
Conference Title
Nur77: new insights in signaling and mechanism of activation of epithelial-mesenchymal transition and tumor metastasis
Presentation Title
Keywords
epithelial-mesenchymal transition, FKBP38, metastasis, mTORC1, Nur77
Discipline
Molecular Biology
Panel
Physical Sciences (P)
HKU Project Code
N_HKU740/14
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2014
Status
Completed
Objectives
(1) To investigate Nur77, FKBP38, Rheb and mTORC1 interactions in the postulated crosstalk events, and the subsequent activation and signaling mechanisms; (2) To determine the cellular effects mediated by the Nur77-mTORC1 signaling axis on EMT and tumor metastasis; (3) To elucidate the role of honokiol and its derivatives in the regulation of the Nur77-FKBP38/Rheb-mTORC1 axis, and with the use of animal models to explore potential clinical effects.