Nur77: new insights in signaling and mechanism of activation of epithelial-mesenchymal transition and tumor metastasis


Grant Data
Project Title
Nur77: new insights in signaling and mechanism of activation of epithelial-mesenchymal transition and tumor metastasis
Principal Investigator
Professor Wong, Alice Sze Tsai   (Principal investigator)
Co-Investigator(s)
Dr Zeng Jin-Zhang   (Co-principal investigator)
Duration
48
Start Date
2015-01-01
Completion Date
2018-12-31
Amount
1097512
Conference Title
Presentation Title
Keywords
Nur77, mTORC1, FKBP38, epithelial-mesenchymal transition, metastasis
Discipline
Molecular Biology
Panel
Physical Sciences
Sponsor
NSFC/RGC Joint Research Scheme
HKU Project Code
N_HKU740/14
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2014/2015
Status
On-going
Objectives
(1) To investigate Nur77, FKBP38, Rheb and mTORC1 interactions in the postulated crosstalk events, and the subsequent activation and signaling mechanisms; (2) To determine the cellular effects mediated by the Nur77-mTORC1 signaling axis on EMT and tumor metastasis; (3) To elucidate the role of honokiol and its derivatives in the regulation of the Nur77-FKBP38/Rheb-mTORC1 axis, and with the use of animal models to explore potential clinical effects.