Rat Model for Developmental Lumbar Spinal Stenosis


Grant Data
Project Title
Rat Model for Developmental Lumbar Spinal Stenosis
Principal Investigator
Dr Cheung, Jason Pui Yin   (Principal investigator)
Co-Investigator(s)
Dr Yeung Kelvin Wai Kwok   (Co-Investigator)
Dr Leung Victor Yu Leong   (Co-Investigator)
Dr Hu Yong   (Co-Investigator)
Duration
12
Start Date
2015-06-30
Completion Date
2016-06-29
Amount
35400
Conference Title
Presentation Title
Keywords
Developmental Spinal Stenosis, Rat model, Lumbar spine
Discipline
Orthopaedics/Traumatology
Panel
Medicine
Sponsor
Block Grant Earmarked for Research (104)
HKU Project Code
201411159078
Grant Type
Seed Fund for Basic Research
Funding Year
2014/2015
Status
On-going
Objectives
Despite the work regarding its phenotype on MRI and genetic origins(9-11), the prevalence, clinical presentation or natural history of DSS is still unknown. Thus, further investigation into the relationship between canal stenosis and symptoms is required to better understand this pathology. Our hypothesis is that there is an inverse relationship between DSS degree and the amount of further compression required to cause symptoms and the severity of soft tissue hypertrophy. In addition, DSS has reduced threshold to chronic compression. The initial step for testing our hypothesis is to apply an animal model. Although there are models to test degenerative spinal stenosis from a one-directional compression(12-19), these models can only recreate the anterior compression that mimics disc protrusions and posterior compression to mimic ligamentum flavum and facet hypertrophy. Currently, there are no options to test DSS which is a circumferential compression of the dura sac. Hence, the objectives of this study is to create a reproducible rat model representing lumbar DSS.