Rat Model for Developmental Lumbar Spinal Stenosis
Dr Cheung, Jason Pui Yin (Principal investigator)
Developmental Spinal Stenosis, Rat model, Lumbar spine
Block Grant Earmarked for Research (104)
HKU Project Code
Seed Funding Programme for Basic Research
Despite the work regarding its phenotype on MRI and genetic origins(9-11), the prevalence, clinical presentation or natural history of DSS is still unknown. Thus, further investigation into the relationship between canal stenosis and symptoms is required to better understand this pathology. Our hypothesis is that there is an inverse relationship between DSS degree and the amount of further compression required to cause symptoms and the severity of soft tissue hypertrophy. In addition, DSS has reduced threshold to chronic compression. The initial step for testing our hypothesis is to apply an animal model. Although there are models to test degenerative spinal stenosis from a one-directional compression(12-19), these models can only recreate the anterior compression that mimics disc protrusions and posterior compression to mimic ligamentum flavum and facet hypertrophy. Currently, there are no options to test DSS which is a circumferential compression of the dura sac. Hence, the objectives of this study is to create a reproducible rat model representing lumbar DSS.