Deciphering the role of the long noncoding RNA Maternally Expressed 3 (MEG3) in hepatic lipid metabolism


Grant Data
Project Title
Deciphering the role of the long noncoding RNA Maternally Expressed 3 (MEG3) in hepatic lipid metabolism
Principal Investigator
Dr Wong, Chi Ming   (Principal investigator)
Duration
24
Start Date
2015-06-30
Completion Date
2017-06-29
Amount
82600
Conference Title
Presentation Title
Keywords
MEG3, lipid metabolism, adeno-associated virus vector-mediated gene delivery system, epigenetic modification, long noncoding RNA
Discipline
Endocrinology,Diabetes/Metabolism
Panel
Medicine
Sponsor
Block Grant Earmarked for Research (104)
HKU Project Code
201411159186
Grant Type
Seed Fund for Basic Research
Funding Year
2014/2015
Status
Completed
Objectives
It is well documented that obesity in one or both parents probably influences the risk of obesity in their offspring because of shared genes or environmental factors within families. However, little is known about bout its underlying mechanism. Potential mechanisms such as metabolic/hormonal theories and epigenetic modification and placental effect were proposed (Battista et al., 2011). Interestingly, two recent studies show that the effects of what obese rodents can pass on their obese phenotype to the next generation by non-genetic intergenerational transmission (Dunn and Bale, 2009; Ng et al., 2010). The offspring of obese rodents were more likely to get type 2 diabetes than the control groups by altering their epigenome (Dunn and Bale, 2009). Maternal antioxidant supplementation could prevent adiposity in the offspring of Western diet-fed dams (Ng et al., 2010). In this study, we are going to investigate the role of imprinted gene Maternally Expressed Gene 3 (MEG3) in the transmission of obesity-related diseases from obese parents to offspring. In this project, we are going to Objectives: 1. To explore the expression pattern of MEG3 at different metabolic stages in both dams and their offspring 2. To define the molecular mechanism of how MEG3 regulate lipid metabolism