Translational meta-analysis for elderly lung cancer patients
Grant Data
Project Title
Translational meta-analysis for elderly lung cancer patients
Principal Investigator
Dr Pang, Hei Man Herbert
(Principal Investigator (PI))
Duration
29
Start Date
2013-12-16
Completion Date
2016-05-31
Amount
201500
Conference Title
Translational meta-analysis for elderly lung cancer patients
Keywords
Meta-analysis
Discipline
Cancer
HKU Project Code
N/A
Grant Type
National Institutes of Health, US Department of Health and Human Services - General Award
Funding Year
2014
Status
Completed
Objectives
Specifi Aim 1: Using elderly lung cancer data aggregated from hundreds of clinical trials, we compare 1a) efficacy and toxicity of sequential chemotherapy and radiation vs. concurrent chemoradiotherapy in locally advanced Non-Small Cell Lung Cancer; and 1b) the efficacy and toxicity of platinum vs. non-platinum-based therapy in extensive and limited Small Cell Lung Cancer patients with different baseline characteristics. Specific Aim 2: We will 2a) build the EPI, a predictive model that helps assign elderly patients in elderly-specific trials; and 2b) utilize statistical methods for causal inference to evaluate and control the impact of imbalanced baseline covariates