An Investigation into the Pre-clinical Efficacy of Monoclonal Antibody against Cadherin-17 and its Combined Treatment with Chemotherapeutic Drugs using Live Imaging in an Orthotopic Tumor Xenograft Model

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Grant Data
Project Title
An Investigation into the Pre-clinical Efficacy of Monoclonal Antibody against Cadherin-17 and its Combined Treatment with Chemotherapeutic Drugs using Live Imaging in an Orthotopic Tumor Xenograft Model
Principal Investigator
Dr Lee, Nikki Pui Yue   (Project Coordinator (PC))
Co-Investigator(s)
Dr Sun Stella   (Co-Investigator)
Duration
7
Start Date
2013-04-02
Amount
100380
Conference Title
An Investigation into the Pre-clinical Efficacy of Monoclonal Antibody against Cadherin-17 and its Combined Treatment with Chemotherapeutic Drugs using Live Imaging in an Orthotopic Tumor Xenograft Model
Presentation Title
Keywords
Monoclonal Antibody
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
InP/020/13
Grant Type
Innovation and Technology Fund Internship Programme
Funding Year
2012
Status
Completed
Objectives
(1) Production of monoclonal antibody against cadherin-17 (anti-CDH17) in mouse ascites (2) Development of orthotopic tumor xenograft mouse model using luciferase-expressing MHCC97L hepatocellular carcinoma cells (3) Testing of different treatment regimens using anti-CDH17 alone or in combination with chemotherapeutic drugs (cisplatin and epirubicin) in orthotopic tumor-bearing nude mice (4) Molecular studies of the tumor xenografts in the aspects of cellular apoptosis and cadherin-17-related cellular pathway using biochemical methods including TUNEL assay, western blot and immunohistochemistry and life-span study of treated mice (5) Publication of research findings in top-tier journal