Discovery and Validation of antiviral small-molecule inhibitors for influenza virus replication


Grant Data
Project Title
Discovery and Validation of antiviral small-molecule inhibitors for influenza virus replication
Principal Investigator
Dr Yang, Lai Hung   (Principal investigator)
Co-Investigator(s)
Ms Law Hing Yee   (Co-Investigator)
Duration
28
Start Date
2012-02-01
Completion Date
2014-05-31
Amount
992000
Conference Title
Presentation Title
Keywords
molecular docking, small molecules, influenza, anti-viral, bioassay, virus replication
Discipline
Others - Medicine, Dentistry and Health
Panel
Medicine
HKU Project Code
11101072
Grant Type
Research Fund for the Control of Infectious Diseases - Full Grants
Funding Year
2011/2012
Status
Completed
Objectives
To further extend the antiviral studies to a list of compounds identified by molecular docking in vitro and then in vivo. The specific aims are: 1) in vitro activity of individual compounds identified by molecular docking; 2) Antiviral activity of individual compounds in vivo. Supplemented by virus-cell culture assays to confirm the antiviral effects in vitro and in vivo, this technology can expedite the discovery of new anti-influenza drugs.