Dataset

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Title of Dataset
GSE25257: Expression data from wild-type and Zmpste24-/- mouse embryonic fibroblasts (MEFs) at an early passage (passage 3, P3)
Author of Dataset
Zhang, Le1
Niu, Gang1
Zhou, Zhongjun1
Contact
Niu, Gang1
Date of Dataset Creation
2010-11-10
Description
Zmpste24 is a metalloproteinase processing prelamin A into mature lamin A, a nuclear structure protein. Zmpste24-/- mice which accumulate prelamin A in cells recapitulate accelerated aging phenotypes observed in human premature aging disorder, Hutchinson Gilford progeria sydrome (HGPS). Zmpste24-/- mouse embryonic fibroblasts (MEFs) exhibited genomic instabiliy and accelerated aging at cellular level, which is premature senescence.<br />We performed microarray analysis on Zmpste24-/- MEFs, compared to wild-type littermates' MEFs, at an early passage (P3), which is a pre-symptom stage before cellular senescence occurs in the mutant MEFs, in order to examine gene expression profile and figure out the underneath mechanism triggering the premature aging process.
Citation
Zhang, L, Niu, G, Zhou, Z. (2010). GSE25257: Expression data from wild-type and Zmpste24-/- mouse embryonic fibroblasts (MEFs) at an early passage (passage 3, P3). [Data File]. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE25257
Subject (RGC Codes)
M1 — Biological Sciences — 生物科學
  • 1128 — Genetics — 遺傳學
Subject (ANZSRC)
06 — BIOLOGICAL SCIENCES — 生物科學
  • 0604 — GENETICS — 遺傳學
    • 060405 — Gene Expression (incl. Microarray and other genome-wide approaches) — 基因表現
Keyword
Mus musculus
Affiliations
  1. The University of Hong Kong, Dept. Biochemistry, #21, Rd. Sassoon, Hong Kong, China