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Article: Loading doses for costly cancer biologicals: Sound pharmacology or unnecessary extravagance?

TitleLoading doses for costly cancer biologicals: Sound pharmacology or unnecessary extravagance?
Authors
Epstein, RJCheung, BMY
KeywordsCost-effectiveness
Health economics
Medical oncology
Pharmacokinetics
Issue Date2008
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejca
Citation
European Journal Of Cancer, 2008, v. 44 n. 11, p. 1488-1492 How to Cite?
DOI: http://dx.doi.org/10.1016/j.ejca.2007.12.006
AbstractThe rising cost of new molecularly-targeted anticancer drugs has become a major issue in oncology. One small but significant factor contributing to this problem is the routine co-administration of loading doses, which may inflate the cost of the first treatment by as much as US$1000. Here, we question the cost-effectiveness of this practice in cancer patients on several grounds, including non-urgent pace of disease, lack of evidence for survival benefit, weak dose-dependency of biopharmaceutical efficacy in cancer and the unproven validity of the 'volume of distribution' concept applied to target-specific drugs. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/78618
ISSN
0959-8049
2021 Impact Factor: 10.002
2020 SCImago Journal Rankings: 3.354
ISI Accession Number ID
WOS:000258254000012
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorEpstein, RJen_HK
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2010-09-06T07:44:52Z-
dc.date.available2010-09-06T07:44:52Z-
dc.date.issued2008en_HK
dc.identifier.citationEuropean Journal Of Cancer, 2008, v. 44 n. 11, p. 1488-1492en_HK
dc.identifier.issn0959-8049en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78618-
dc.description.abstractThe rising cost of new molecularly-targeted anticancer drugs has become a major issue in oncology. One small but significant factor contributing to this problem is the routine co-administration of loading doses, which may inflate the cost of the first treatment by as much as US$1000. Here, we question the cost-effectiveness of this practice in cancer patients on several grounds, including non-urgent pace of disease, lack of evidence for survival benefit, weak dose-dependency of biopharmaceutical efficacy in cancer and the unproven validity of the 'volume of distribution' concept applied to target-specific drugs. © 2007 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejcaen_HK
dc.relation.ispartofEuropean Journal of Canceren_HK
dc.subjectCost-effectivenessen_HK
dc.subjectHealth economicsen_HK
dc.subjectMedical oncologyen_HK
dc.subjectPharmacokineticsen_HK
dc.subject.meshAntineoplastic Agents - economics - pharmacokinetics - therapeutic use-
dc.subject.meshBiological Products - economics/pharmacokinetics - therapeutic use-
dc.subject.meshDrug Administration Schedule-
dc.subject.meshNeoplasms - drug therapy - economics-
dc.subject.meshDrug Costs-
dc.titleLoading doses for costly cancer biologicals: Sound pharmacology or unnecessary extravagance?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-8049&volume=44&issue=11&spage=1488&epage=92&date=2008&atitle=Loading+doses+for+costly+cancer+biologicals:+sound+pharmacology+or+unnecessary+extravagance?en_HK
dc.identifier.emailEpstein, RJ: repstein@hku.hken_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.authorityEpstein, RJ=rp00501en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejca.2007.12.006en_HK
dc.identifier.pmid18194858-
dc.identifier.scopuseid_2-s2.0-46249101531en_HK
dc.identifier.hkuros150571en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46249101531&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1488en_HK
dc.identifier.epage1492en_HK
dc.identifier.isiWOS:000258254000012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridEpstein, RJ=34975074500en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.issnl0959-8049-

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