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Article: Telomerase activation in human cancers

TitleTelomerase activation in human cancers
Authors
Tsao, SWZhang, DKCheng, RYSWan, TSK
Issue Date1998
PublisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 1998, v. 111 n. 8, p. 745-750 How to Cite?
AbstractObjective To review the background of telomerase activation and the methodology involved in its determination, and the clinico-pathological significance of telomerase activation in human cancers. Data sources An English-language literature search using MEDLINE (1966-1997) and bibliographic reviews of textbooks and review articles. Results Progressive shortening of telomeres was associated with continuous cell division in normal somatic cells. Telomerase was activated in most cancer cells and immortal germ cells to maintain their telomeric lengths. The occurrence and clinical pathological significance of telomerase activation was evaluated in various types of human cancer. Conclusions Telomerase activation is a common event in human cancers and may be as a useful marker for malignant cells. Telomerase may also be a therapeutic target for cancer treatment.
Persistent Identifierhttp://hdl.handle.net/10722/67414
ISSN
0366-6999
2021 Impact Factor: 6.133
2020 SCImago Journal Rankings: 0.537
ISI Accession Number ID
WOS:000075504700018
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorZhang, DKen_HK
dc.contributor.authorCheng, RYSen_HK
dc.contributor.authorWan, TSKen_HK
dc.date.accessioned2010-09-06T05:54:56Z-
dc.date.available2010-09-06T05:54:56Z-
dc.date.issued1998en_HK
dc.identifier.citationChinese Medical Journal, 1998, v. 111 n. 8, p. 745-750en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67414-
dc.description.abstractObjective To review the background of telomerase activation and the methodology involved in its determination, and the clinico-pathological significance of telomerase activation in human cancers. Data sources An English-language literature search using MEDLINE (1966-1997) and bibliographic reviews of textbooks and review articles. Results Progressive shortening of telomeres was associated with continuous cell division in normal somatic cells. Telomerase was activated in most cancer cells and immortal germ cells to maintain their telomeric lengths. The occurrence and clinical pathological significance of telomerase activation was evaluated in various types of human cancer. Conclusions Telomerase activation is a common event in human cancers and may be as a useful marker for malignant cells. Telomerase may also be a therapeutic target for cancer treatment.en_HK
dc.languageengen_HK
dc.publisherZhonghua Yixuehui. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subject.meshBrain Neoplasms - enzymologyen_HK
dc.subject.meshLung Neoplasms - enzymologyen_HK
dc.subject.meshNeoplasms - enzymologyen_HK
dc.subject.meshNeuroblastoma - enzymologyen_HK
dc.subject.meshTelomerase - metabolismen_HK
dc.titleTelomerase activation in human cancersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0366-6999&volume=111&issue=8&spage=745&epage=750&date=1998&atitle=Telomerase+activation+in+human+cancersen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11245033en_HK
dc.identifier.scopuseid_2-s2.0-0032129561en_HK
dc.identifier.hkuros33616en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032129561&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue8en_HK
dc.identifier.spage745en_HK
dc.identifier.epage750en_HK
dc.identifier.isiWOS:000075504700018-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridZhang, DK=7405361705en_HK
dc.identifier.scopusauthoridCheng, RYS=7201955319en_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.issnl0366-6999-

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