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- Publisher Website: 10.1016/j.eng.2021.11.012
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Article: Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence
Title | Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence |
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Authors | |
Keywords | Immunology Liver cancer Liver transplantation Recurrence |
Issue Date | 2022 |
Citation | Engineering, 2022, v. 10, p. 57-64 How to Cite? |
Abstract | Hepatic malignancy is a major indication for liver transplantation; however, post-transplant cancer recurrence is an emerging clinical challenge affecting long-term outcomes. Pre-transplant tumor biology, staging, and post-transplant immunosuppression regimens have been elucidated as risk factors for recurrent liver cancer. However, increasing evidence indicates that hepatic ischemia and reperfusion (IR) injury to allografts are crucial to providing a favorable immunologic microenvironment for cancer cell invasiveness and metastasis after liver transplantation. The association of severe graft injury in marginal grafts, such as small-for-size or fatty grafts, with lower recurrence-free survival rates in living donor liver transplantations, substantiates the correlation between hepatic IR injury and cancer recurrence. IR has been demonstrated to trigger intrahepatic immunological microenvironment remodeling, including pro-inflammatory responses exacerbating graft injury and anti-inflammatory responses promoting tissue repair. However, the role of regional immunity in post-transplant cancer recurrence is not comprehensively understood. This review describes the up-to-date evidence of the intrahepatic humoral microenvironment and regional regulatory immunological microenvironment induced by IR injury, as well as their roles in cancer recurrence after liver transplantation. A comprehensive understanding of regional immunity will provide novel precise diagnostic, therapeutic, and prognostic strategies for post-transplant cancer recurrence. |
Persistent Identifier | http://hdl.handle.net/10722/342648 |
ISSN | 2023 Impact Factor: 10.1 2023 SCImago Journal Rankings: 1.646 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Jiang | - |
dc.contributor.author | Lo, Chung Mau | - |
dc.contributor.author | Man, Kwan | - |
dc.date.accessioned | 2024-04-17T07:05:16Z | - |
dc.date.available | 2024-04-17T07:05:16Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Engineering, 2022, v. 10, p. 57-64 | - |
dc.identifier.issn | 2095-8099 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342648 | - |
dc.description.abstract | Hepatic malignancy is a major indication for liver transplantation; however, post-transplant cancer recurrence is an emerging clinical challenge affecting long-term outcomes. Pre-transplant tumor biology, staging, and post-transplant immunosuppression regimens have been elucidated as risk factors for recurrent liver cancer. However, increasing evidence indicates that hepatic ischemia and reperfusion (IR) injury to allografts are crucial to providing a favorable immunologic microenvironment for cancer cell invasiveness and metastasis after liver transplantation. The association of severe graft injury in marginal grafts, such as small-for-size or fatty grafts, with lower recurrence-free survival rates in living donor liver transplantations, substantiates the correlation between hepatic IR injury and cancer recurrence. IR has been demonstrated to trigger intrahepatic immunological microenvironment remodeling, including pro-inflammatory responses exacerbating graft injury and anti-inflammatory responses promoting tissue repair. However, the role of regional immunity in post-transplant cancer recurrence is not comprehensively understood. This review describes the up-to-date evidence of the intrahepatic humoral microenvironment and regional regulatory immunological microenvironment induced by IR injury, as well as their roles in cancer recurrence after liver transplantation. A comprehensive understanding of regional immunity will provide novel precise diagnostic, therapeutic, and prognostic strategies for post-transplant cancer recurrence. | - |
dc.language | eng | - |
dc.relation.ispartof | Engineering | - |
dc.subject | Immunology | - |
dc.subject | Liver cancer | - |
dc.subject | Liver transplantation | - |
dc.subject | Recurrence | - |
dc.title | Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.eng.2021.11.012 | - |
dc.identifier.scopus | eid_2-s2.0-85126923828 | - |
dc.identifier.volume | 10 | - |
dc.identifier.spage | 57 | - |
dc.identifier.epage | 64 | - |
dc.identifier.isi | WOS:000807736400009 | - |